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Health Care for Guinea Pigs

General Information
Guinea pigs are rodents (related to
chinchillas and porcupines) that originated from the
Andes Mountains region of South American. In the 16th
century, Dutch explorers introduced guinea pigs to
Europe, at which time selective breeding and captive
rearing begin in earnest. These activities have continued
to the present. Guinea pigs are extremely popular pets
today because of their availability, docile temperaments,
tendency not to bite or scratch when handled and
because of their relatively clean habits. They are not
terribly long-lived which can be disconcerting to owners
(especially children). In their natural habitat, guinea pigs live in
open, grassy areas. They prefer to seek shelter in naturally
protected areas or within burrows created and later deserted by other
animals. Guinea pigs are sociable animals and tend to live in
groups. They are strictly herbivorous (plant-eating) and do most of
their foraging for grasses, roots, fruits and seeds in the late afternoons
and early evenings as the daylight wanes.
Handling-Restraint
Guinea pigs rarely violently struggle when
they are being picked up but often make their
"squeal of protest" which sounds pig-like to
many. Nevertheless, great care should be taken not to
injure them during this activity. The guinea pig to be
lifted should be approached with two hands. One is placed
under the guinea pig's chest and abdomen and the other
supports its hindquarters. Adults and those that are
pregnant should receive careful attention to gentle, but
firm and total support. One of the most desirable features of
guinea pigs as pets is that they rarely bite when being
handled or restrained. Housing
Proper, adequate housing is a major factor
in the maintenance of healthy guinea pigs. The
psycho-social well-being of the animals must be a primary
consideration. Guinea pigs can be housed within
enclosures made of wire, stainless steel, durable plastic
or glass. The latter three materials are preferred
because they resist corrosion. Wood and similar materials
should not be included in the construction of enclosures
because they are difficult to clean and these materials
cannot withstand the destructive gnawing of the
occupant(s). The construction and design of the enclosure
must ensure that the resident(s) cannot escape. Furthermore, the enclosure must be free of sharp edges
and other potential hazards. The enclosure must be roomy enough to
allow the resident(s) to pursue normal activities and
breeding activity, if the latter is desired. The enclosure can be open at the top
provided that its sides are at least 7 to 8 inches high.
Male guinea pigs (especially breeding males) will require
the sides of their enclosures to be at least 10 inches
high. They tend to be more rambunctious. Enclosures that provide solid flooring and
an adequate supply of a preferred bedding are the best
for pet guinea pigs. They should be easy to clean, well
lighted and adequately ventilated. Bedding must be clean,
non-toxic, absorbent, relatively dust-free and easy to
replace. Shredded paper, wood shavings, and processed
corn cob are preferred bedding materials. Sawdust should
be avoided as well as cedar chips. Cedar chips and sometimes pine
chips can be irritating and cause allergic reactions to some
guinea pigs. Guinea pigs can be housed on wire mesh
(that which is suitable for housing rats can be used) but
it is not recommended. Such material will allow urine and
most fecal pellets to drop through, thereby keeping the
bedding and the resident "pig(s)" cleaner.
Guinea pigs housed for long periods on wire, however,
tend to develop serious injuries to the bottom of their
feet. Furthermore, broken legs are quite common when
guinea pigs fall through the mesh. This is most often a
problem with guinea pigs that have not been reared on
wire mesh, and occurs soon after they have been
introduced onto it. Guinea pigs seem most comfortable when
they are spared exposure to excessive noise, needless
excitement and confusion, and other similar or perceived
stresses. Sudden environmental changes should also be
prevented. Effects of Noise
Guinea pigs exhibit two types of reactions
when startled by a loud noise, sudden movement, or
strange environment. They may "freeze" completely
motionless (for up to 20 minutes) or panic. The latter
reaction involves erratic running and leaping, often
accompanied with shrill squealing. Groups of guinea pigs
will stampede in a circle, often trampling the younger
residents within the enclosure. A panic reaction will
scatter bedding and food, fouling the food and water
containers. Visual security (a place into or under which
the resident(s) can retreat when frightened) should
always be provided. Hygiene
The frequency with which the enclosure is cleaned will depend on its
design, the materials out of which it is made, and the number of guinea pigs
that reside within it. As a general rule of thumb, the enclosure and
all cage "furniture" should be cleaned and disinfected once weekly.
The food and water containers should receive cleaning and disinfection once
daily. We suggest that more than one set of containers be maintained
and the "used" set be washed in a dishwasher, if possible. A vigorous
scrubbing of the enclosure and "furniture" with hot water and soap and a
thorough rinse should be followed by the use of a disinfectant. Food and Water
Good quality food and fresh, clean water
must be readily available at all times. The exact
nutritional requirements of the guinea pig are known and
commercially available pelleted food provide all of the
essential nutrients, as long as the pellets are fresh and
wholesome when offered. Some guinea pig owners will be
tempted to feed rabbit pellets, assuming that they are
roughly equivalent to guinea pig pellets. They are not
equivalent. Unlike most mammals (including rabbits),
guinea pigs require a high level of vitamin C. Unlike rabbits, guinea pigs cannot manufacture
their own vitamin C and must receive it from an outside
source. Interestingly, man and his primate relatives
share this metabolic inability and dependence on vitamin
C from the food that they consume. Pellets milled for
guinea pigs take these special requirements into
consideration and are appropriately fortified with these
two nutrients, among many other essential ones. Guinea pig food generally contains 18
percent to 20 percent protein, 16 percent fiber and
approximately one gram of vitamin C per kilogram of
ration. Even when the fresh pellets are properly stored
in a cool, dry place, approximately one half of the
vitamin C content is degraded and lost within six weeks
of manufacture. Therefore, we recommend that the diet be
supplemented with vitamin C as follows: 200 milligrams
ascorbic acid (= vitamin C) added to approximately one
quart of drinking water, make up fresh every 12 hours, or
a single guinea pig should be offered one handful of kale
or cabbage or one quarter of an orange daily. We recommend that fresh
greens and timothy hay be provided daily. Fruit in small
amounts can be offered daily. Fresh items must be thoroughly washed to
avoid exposing pet guinea pigs to pesticide residues and
possible bacterial contamination. All foods should be provided in heavy
ceramic crocks that resist tipping over. The crocks
should possess high enough sides to keep bedding and
fecal pellets out of the food or the crocks should be
elevated slightly above the bedding. Water is most easily made available and
kept free from contamination by providing it in one or
more water bottles equipped with "sipper"
tubes. Guinea pigs tend to contaminate and clog their
water bottles more than other pet rodents by chewing on
the end of the sipper tube and "backwashing"
food particles into it. For this reason, it is imperative
that all food and water containers be cleaned and
disinfected frequently. Guinea pigs tend to be creatures of habit
and do not tolerate changes in the presentation of their
food and water or changes in the taste, texture or
form of the food itself. Pet owners should avoid making
radical changes in the food and water containers used and
changes in the food itself should be made gradually.
Failure to do so usually results in guinea pigs refusing
food and water, which can be disconcerting and dangerous. Breeding Considerations
The single most important breeding
consideration is that female guinea pigs should
participate in their first breeding before seven
months of age. If the first breeding is delayed
beyond this time, serious (sometimes
life-threatening) problems with delivery are
encountered. Female "pigs" should be
first bred between 3 and 7 months of age. Males
should be 3 to 4 months old at their first
breeding. The guinea pig's heat cycle last
16 days. The actual period during which the
female is receptive to the male and will allow
breeding is approximately 8 hours. Female guinea
pigs are capable of coming back into heat 6 to 15
hours after giving birth. This is called a
"postpartum estrus" which means that
they can be nursing a litter and pregnant at the
same time! Pregnancy lasts an average of 63 to
68 days. The larger the litter size, the shorter
the term and vice versa. The duration of
pregnancy for guinea pigs is unusually long when
compared with that of other rodents. Pregnant sows exhibit a grossly
enlarged abdomen during the latter stages of
pregnancy. It is not uncommon for their body
weight to double during pregnancy. The time of
delivery may be difficult to determine because of
the relatively long gestation period and because
pregnant sows do not build nests into which their
young would otherwise be delivered. The pet owner
attending a near term sow will feel a slowly
widening separation of the pelvis just in front
of the external genitalia of the pregnant sow
within the week prior to delivery. This
separation reaches slightly more than one inch in
the hours just prior to delivery. This separation of the pelvis
fails to take place in females that are bred for
the first time after seven months of age,
creating an impossible and tragic situation.
Delivery of the young is not possible and a
caesarean section must usually be performed in
order to save the life of the sow and her babies. An uncomplicated delivery usually
requires about ½ hour with an average of five
minutes between babies. Litter sizes range from
one to six young with three to four being
average. Litters resulting from the first
breeding are usually very small. Abortions and
stillbirths are common occurrences with guinea
pigs throughout their breeding lives. The young are born relatively
developmentally advanced. They are unusually
large and fully-furred and capable of walking
about. Furthermore, they possess teeth and open
eyes at this time. Even though the newborn
"pigs" are capable of eating solid food
and drinking water from a container, it is
recommended that they be allowed to nurse their
mother for at least 2 weeks.

Common Conditions
Requiring Veterinary Medical Attention
Non-Infectious Conditions
Malocclusion of Premolar Teeth
(Slobbers). A common problem of guinea pigs
(especially those over two to three years old)
results when the upper and lower premolar teeth
(the most forward-positioned of the cheek teeth)
meet improperly while chewing. In time, this
problem results in abnormal wear of these teeth.
This problem results in signs and symptoms that
will surely be of concern to the guinea pig owner: desire to eat but inability to chew and
swallow food, drooling resulting in a continually
moist mouth and chin, and weight loss. There is no permanent
solution or correction for this problem. Periodic
trimming/filing is almost always necessary.
Guinea pigs with this problem should never be
bred in order to prevent passing this most
undesirable trait to their offspring. Vitamin C Deficiency (Scurvy). As discussed in the section on
Food and Water, guinea pigs (like man) cannot
manufacture vitamin C and must receive an
adequate supply of it from an outside food source.
Failure to do so results in scurvy, the symptoms
of which include inappetence; swollen, painful
joints and ribs; reluctance to more; poor bone
and teeth development and spontaneous bleeding
from the gums and into muscle. This mandatory vitamin C
requirement is well known to those who
manufacture the pelleted diets for guinea pigs
and adequate levels of this vitamin are always
included in the formulation of them. Often,
handling and improper storage (exposure to light,
heat and dampness) of these pellets results in
loss of potency of the vitamin C. Therefore even
pet guinea pigs fed presumably reliable pelleted
diets may exhibit signs of scurvy if the potency
of the vitamin C within them has been reduced or
lost. Difficulty with Delivery of
Young (Dystocia). Signs of dystocia include
straining and uterine bleeding. An owner of a
guinea pig exhibiting these symptoms must seek
veterinary help immediately. The veterinarian
will evaluate the pregnant sow by direct exam and
by taking x-rays. If a vaginal delivery of the
young is not possible, then a caesarean section
will be advised. Pregnancy Toxemia.
Pregnancy toxemia is a serious condition of
usually overweight sows most often in their first
or second pregnancies. Symptoms of this condition
are most likely to be noted within the last two
weeks of pregnancy or the first week following
same and include: inappetence, depression,
weakness, reluctance to move, incoordination,
difficulty breathing, coma and death. These
symptoms may be noted over a one to five day
period. Some afflicted sows may show no symptoms
and suddenly die. There is no single cause
for this condition but stress and obesity are
major predisposing factors. Others include
advancing age, lack of exercise, fasting just
prior to onset of symptoms, and a large number of
developing fetuses. The fundamental underlying
problem appears to be an inadequate blood flow,
and hence, nutrient supply, to the pregnant
uterus. Pregnant sows or those which have
recently delivered that exhibit any of the
aforementioned symptoms must be seen immediately
by a veterinarian. Treatment is directed towards
reversing the low blood sugar, acidic pH of the
blood and accumulation of ketones within it, but
such attempts are often unsuccessful. Prevention of pregnancy toxemia is
of paramount importance. Pregnant sows should be
prevented from becoming obese. Fasting and
stresses of all kinds must be avoided, especially
in the last several weeks of pregnancy. Pregnant
sows must be supplied with fresh water at all
times and a nutritious diet. Hair Loss. Hair loss or
thinning of the hair is a common problem of
female guinea pigs that have been repeatedly
bred. These sows tend to lose hair with each
successive pregnancy. Hair loss is frequently noted
among juvenile guinea pigs in a weakened state at
or around the time of weaning.
"Barbering" also results in hair loss.
The vice (bad habit) occurs when guinea pigs
habitually chew on the hair coats of
"pigs" that are lower in the social
"pecking order". Younger guinea pigs,
in particular, can lose substantial amounts of
hair as a result of the activity. Heat Stress (Stroke).
Guinea pigs are especially susceptible to heat
stroke, particularly those that are overweight or
heavily furred. Environmental temperatures above
85 degrees Fahrenheit, high humidity (above 70
percent), inadequate shade and ventilation,
crowing and physiological stress are additional
predisposing factors. Signs of heat stroke include
panting, slobbering, weakness and refusal to move
about, delirium, convulsions and eventually
death. Heat stroke is a treatable condition if
recognized relatively early. Heat-stressed guinea
pigs should either be sprayed with cool water or
be bathed in cool water. Once this first aid
measure is undertaken, a veterinarian should be
contacted immediately. Prevention of heat stroke involves
of heat stroke involves providing adequate shade
from the sun (if guinea pig(s) are house
outdoors) and adequate ventilation (if guinea
pig(s) are housed indoors). Furthermore, a
continuous light mist or spray of water or a fan
operating over a container of ice can be directed
at a guinea pig within its enclosure in order to
lower the air temperature, whether the guinea pig
is housed indoors or outdoors.
INFECTIOUS CONDITIONS
Bacterial Infections
Footpad Infections (Bacterial
Pododermatitis). Serious (sometimes
crippling) infections of the footpads are
extremely common among pet guinea pigs housed
continuously on wire. The other major
predisposing factor is fecal soiling of
wire-bottomed enclosures. The front feet of
overweight "pigs" are especially
vulnerable to this condition.
Symptoms of this condition include
swelling of a foot (of the feet), lameness,
reluctance to move, and inappetence. The flooring
of the enclosure must be changed and overall
sanitation must be improved. Furthermore, a
veterinarian must be consulted regarding
treatment of the affected foot (feet). Topical
dressing with an antibiotic and periodic
bandaging will be necessary during the usually
lengthy recovery period. Injectable antibiotics
are often used by veterinarians in the treatment
of this condition. Arthritis is a frequent and
unfortunate consequence of these infections.
Cervical "Lumps". Abscesses of the
lymph nodes immediately beneath the lower jaw in
the upper neck usually results when coarse foods
(such as hay) cause injury to the lining of the
mouth or when superficial wounds penetrate the
skin over these lymph nodes. In both cases,
bacterial invasion is permitted. Symptoms include
firm, painful swelling under the lower jaw. Sometimes these abscesses break open, allowing a
thick, creamy yellow-white pus to issue forth. If the abscesses are large, complete
surgical removal of them will be recommended
along with aggressive antibiotic therapy.
Pneumonia. Pneumonia is one
of the most common bacterial diseases of pet
guinea pigs. A number of potential
disease-causing bacteria may inhabit the
respiratory tracts of otherwise normal guinea
pigs. Conditions of stress, inadequate diet, and
improper home care will often predispose a pet
guinea pig to an opportunistic infection with one
or more of these bacteria. Symptoms of pneumonia
may include labored or rapid breathing, discharge
from eyes or nostrils, lethargy and inappetence;
or no symptoms at all with sudden death.
Intestinal Infections. A number of bacteria
are capable of causing infections of the
gastrointestinal tract of guinea pigs. Some of
these bacteria are introduced on contaminated
greens and vegetables or in contaminated water.
There appears to be two major ways
in which these intestinal infections manifest themselves: sudden death without obvious prior
symptoms or a more lengthy period of illness
characterized by lethargy and marked weight loss. Diarrhea may or may not be noted in either case.
Ringworm. Ringworm is a
skin disease caused by a fungus. Young guinea
pigs are usually more susceptible than adults.
Ringworm in guinea pigs is generally
characterized by patchy hair loss on the face,
nose and ears. The skin in these areas may appear
flaky. The areas of hair loss may extend along
the top side of the trunk of affected guinea
pigs.
Transmission of ringworm from
guinea pig to man is very possible. It is
extremely important to limit or restrict handling
of ringworm-infected guinea pigs (especially by
young children) until their disease has been
successfully treated. If handling of affected
guinea pigs is necessary, the handler should
thoroughly wash his hands afterwards.

Parasitic Disease
External Parasite Problems
Lice Infestation. Lice and
mites are the most common external parasites of
guinea pigs. Lice are tiny, wingless, flattened
insects that live within the hair coats of the
animals they parasitize. In fact, both the adults
and their eggs are found attached to individual
hairs of the hair coat. Light infestations usually go
unnoticed. Heavy infestations are usually
accompanied with excessive itching, scratching
and some hair loss. Scabs may also be evident on
and around the ears. Mite Infestations. Mites are microscopic, spider-like
organisms that live within the top layers of the
skin. Their presence in this location usually
cases intense itching, scratching and significant
hair loss. Some cases without itching and
scratching have been reported. Some guinea pigs
are so miserable because of the infestation that
they will produce serious self-inflicted wounds
and exhibit wild running and circling and
occasionally, even convulsions. Treatment consists of an
injection to kill the mites. Guinea pig mites do
not parasitize man. Intestinal Parasite Problems
Intestinal parasites are usually not a
significant problem in pet guinea pigs. Symptoms of
this disease include weakness, diarrhea and
severe weight loss.
 A Special Comment Regarding The
Extreme Sensitivity of Guinea Pigs To Certain
Antibiotics Guinea pigs as a group are
unusually sensitive to the potentially lethal
effects of certain antibiotics, whether they are
given orally or by injection. The major mechanism for this often
lethal effect of certain antibiotics is the
tremendous alternation that these drugs can cause
to the normal microbial balance within the
gastrointestinal tract.

General Information About Guinea Pigs
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Scientific Name |
Cavia Porcellus |
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Life Span |
3 - 4 years |
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Potential Life Span |
6 - 7 years |
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Desirable Temperature Range |
65 - 75 Degrees Fahrenheit |
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Desirable Humidity Range |
40 - 70 percent (50 percent is considered
ideal) |
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Recommended Age at First
Breeding |
Male: 3 - 4 months
Female: 3 - 6 months
(not after 6 months) |
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Length of Estrous (Heat) Cycle |
16 days |
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Length of Estrus (period during which female is receptive to
male for copulation) |
8 hours |
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Gestation (pregnancy Period) |
Averages between 63 & 68 days |
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Average Litter Size |
3 - 4 young (range 1
- 6) |
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Age at Weaning |
2 - 3 weeks |

Suggested Reading
The Biology and Medicine of Rabbits
and Rodents,
Harkness, John E. and Wagner, Joseph E.
La & Febiger, Philadelphia,
1986 (Second Edition).
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